Reimer has also played in the NHL for the Toronto Maple Leafs, Florida Panthers, San Jose Sharks, Carolina Hurricanes, Detroit Red Wings and Anaheim Ducks.

After turning professional, Reimer played with the South Carolina Stingrays and Reading Royals of the ECHL, as well as the Toronto Marlies of the American Hockey League (AHL).

[2] Reimer played his last seasons of minor hockey for the Interlake Lightning of the Manitoba "AAA" Midget league.

[7] Reimer broke his hand late in the season, an injury which cost him a chance to play for Canada at the 2006 IIHF World U18 Championships.

"[3] His agent, Ray Petkau, called with the news about being drafted and later brought him his Maple Leafs jersey and hat that draftees receive.

[11] In March 2008, the Maple Leafs signed Reimer to a three-year contract worth an annual base salary of $555,000, the minimum for an NHL player at the time.

[12][13] After attending the Maple Leafs' training camp in September 2008, Reimer was assigned to their affiliate, the Toronto Marlies, of the American Hockey League (AHL).

[17] Serving as Joey MacDonald's backup, he did not receive any playing time in his first NHL call-up and was sent back to the Marlies on October 25.

"[18] He was recalled by the Maple Leafs several months into the season, making his NHL debut on December 20, 2010, in relief of Jonas Gustavsson against the Atlanta Thrashers.

[21] A combination of injuries and poor play by Gustavsson and Jean-Sébastien Giguère provided an opportunity for Reimer at the NHL level.

"[22] Ron Wilson acknowledged Reimer as the team's starting goaltender as they set out on a late-season run for a playoff spot, saying, "It's going to be his ball the rest of the way.

"[23] Reimer became a quick fan favourite during his rookie NHL season, earning the nicknames "Optimus Reim" and "The Statue".

[24] The former is a reference to the Transformers protagonist Optimus Prime, while the latter resulted from head coach Wilson's attempts to suppress the hype around the rookie goaltender only a short time into his NHL career, saying, "There's all this [attention] around here, a guy wins a game and we're ready to build a statue for him.

Reimer held off an early challenge from rookie backup Ben Scrivens to remain Toronto's starting goaltender.

[33] Upon returning, Reimer backstopped the Maple Leafs to their first playoff berth since 2004[34] and finishing the regular season with a career best 2.46 GAA and .924 save percentage in 34 games.

[37] On July 25, 2014, the Leafs and Reimer avoided a salary arbitration hearing scheduled for the next week by agreeing to terms on a two-year contract with an average annual value of $2.3 million.

[39] Reimer would hold the position as Maple Leafs' starting goaltender for the rest of his tenure, earning praise for his play on a Toronto team that struggled throughout the year.

[42] On July 1, 2016, as an unrestricted free agent for the first time in his career, Reimer was signed to a five-year contract with the Florida Panthers.

After three seasons with the Florida Panthers, Reimer was traded to the Carolina Hurricanes in exchange for Scott Darling and a 2020 sixth-round draft pick on June 30, 2019.

[44] On July 28, 2021, having left the Hurricanes as an unrestricted free agent, Reimer returned to the San Jose Sharks, signing a two-year, $4.5 million contract.

[45] On July 1, 2023, Reimer signed as an unrestricted free agent to a one-year, $1.5 million contract with the Detroit Red Wings.

[46] On July 1, 2024, Reimer joined his sixth NHL club, initially adding a veteran presence in net to the Buffalo Sabres in signing a one-year, $1 million contract.

[49] Reimer made his debut for the Sabres on November 23 against the San Jose Sharks stopping 31 out of 33 shots and recording the win in a 4–2 victory.

[8] After his strong rookie season in the NHL, Reimer received another invitation from Hockey Canada, this time to compete at the 2011 IIHF World Championship.

Reimer issued a statement reading, in part, "In this specific instance, I am choosing not to endorse something that is counter to my personal convictions which are based on the Bible, the highest authority in my life.