The James S. Thompson House is a historical home located just outside New Boston, in Mercer County, Illinois.

The two story brick Italianate house was completed in 1862, built by James S. Thompson, a successful local businessman.

Stanton V. Prentiss, a local farmer and cattleman rented the property from the estate starting in 1879 and purchased it in 1885.

A front gabled roof, cupola, and a basement that extents about five feet above ground combine to give the house additional stature.

[2] The house and four contributing outbuildings were added to the National Register of Historic Places in 2002.