James Sanders House is a historic home located at Little Falls in Herkimer County, New York.

It consists of a rectangular main block with a two-story brick rear wing.

It features a center hall plan and Federal-style decorative elements.

James Sanders was a local building contractor who also built a number of mills, residences, and civic buildings including the original Little Falls Academy.

This article about a historic property or district in Herkimer County, New York, that is listed on the National Register of Historic Places, is a stub.