He previously played for the Brisbane Broncos, North Queensland Cowboys, Penrith Panthers, Manly Sea Eagles and the Cronulla-Sutherland Sharks in the National Rugby League, and briefly for the Blacktown Workers and Newtown Jets in the NSW Cup.

Born in Papua New Guinea, Segeyaro moved to Cairns, Queensland, Australia with his biological mother at the age of seven.

[9] Segeyaro broke into the North Queensland NRL squad in 2011 after undergoing a shoulder reconstruction at the end of the previous season.

[10] Segeyaro made his NRL debut in Round 3 against the Melbourne Storm playing off the interchange bench in North Queensland's 34–6 win at 1300SMILES Stadium.

[20] Segeyaro played in all the Panthers 24 matches and scored 10 tries in a stellar debut year for the Penrith club in the 2013 NRL season.

[4][29] He explained that he changed his allegiance to Australia due to perceived disrespect from PNG rugby league officials after his father's death.

[31] On Australia Day, Segeyaro received Australian citizenship from Governor-General Peter Cosgrove, having lived in the country for the past 19 years.

[34] In May 2016, Segeyaro was photographed dining with senior bikie Paulie Younan alongside then Parramatta player Corey Norman.

Segeyaro made his debut for Brisbane in Round 10 scoring a try in a 15–10 victory over defending premiers the Sydney Roosters at Suncorp Stadium.

On 27 May, Segeyaro was caught drink driving and blew a blood-alcohol level under 0.05, but as the player is on a provisional licence his reading cannot be above zero.

Segeyaro played his 150th NRL game with Brisbane in round 22 which the club won against the Penrith Panthers at Suncorp Stadium.

Segeyaro made 13 appearances for Brisbane in the 2019 NRL season as the club finished eighth on the table and qualified for the finals.

[51] On 7 February, it was revealed that Segeyaro had signed a one-year deal with NSW Cup side Blacktown Workers, feeder to the Manly-Warringah Sea Eagles.

[52] On 28 July, Segeyaro made his club debut for Manly against the Sydney Roosters off the bench where he played eleven minutes.

[53] Segeyaro owns a clothing business called "YKTR" alongside former Dragons player Corey Norman and ex-player Isaac John.