James Tilghman Lloyd (August 28, 1857 – April 3, 1944) was a Democratic member of the U.S. House of Representatives from Missouri from 1897 to 1917.

He studied law, was admitted to the bar in 1882, and started a practice in Monticello, before moving to Shelbyville in 1885.

In 1916, he led the effort to pass the Lloyd–La Follette Act to provide federal employees with whistleblower protections.

He returned to Canton in 1925 and continued his law practice and was a member of the board of curators of Culver-Stockton College.

He died in Quincy, Illinois on April 3, 1944, and was buried in Forest Grove Cemetery in Canton.