He has previously played in the National Hockey League (NHL) for the Chicago Blackhawks, Anaheim Ducks, New York Islanders, Montreal Canadiens, Columbus Blue Jackets, and Carolina Hurricanes.

However, he tore his anterior cruciate ligament (ACL) during the first period in a game against the Los Angeles Kings on March 5, 2007, and was placed on injured reserve, missing the rest of the season.

[citation needed] On March 4, 2009, Wisniewski was traded by the Blackhawks, along with Finnish forward Petri Kontiola, to the Anaheim Ducks in exchange for Samuel Påhlsson and Logan Stephenson.

On March 17, 2010, in a game against former team, the Blackhawks, Wisniewski delivered a retaliation hit to Brent Seabrook, his former teammate and good friend, driving his head against the glass.

[4] On July 30, 2010, Wisniewski was traded by the Ducks to the New York Islanders for a conditional third-round pick in the 2011 NHL Entry Draft.

[10] In an injury-shortened 2011–12 season, Wisniewski appeared in 48 games with Columbus, scoring six goals along with 21 assists as the Blue Jackets finished well out of the playoff hunt.

[12] On June 27, 2015, the second day of the 2015 NHL Entry Draft, Wisniewski was traded to the Carolina Hurricanes In exchange for Anton Khudobin.

[14] Wisniewski's brief shift with the Hurricanes would be his last, for in the off-season and nearing a return to full health, he was bought out from the final year of his contract on June 30, 2016.

[16] Wisniewski signed with Admiral Vladivostok of the Kontinental Hockey League (KHL) for the 2016–17 season and parted ways with the club in December 2016 after 16 games.