[2] Wuest is most known for his contributions to the development of modular construction, using it as a method for creating molecular materials with predictable structures and properties.

[3] Wuest is a pioneer in modular construction, a method for creating predictably ordered materials by using molecular modules that engage in well-defined associations, thereby holding their neighbors in predetermined positions.

Furthermore, he and his group have investigated the factors contributing to high levels of polymorphism[21][22][23] and their work in this area has led to multiple papers and patents.

[24][25][26][27][28] In this work, Wuest and his research group have used an approach that combines database mining, computational analysis, and experimentation as a way to understand the rules of crystallization, expand the range of known molecular behavior, and find new crystalline materials.

They have reviewed various aspects of the field[29][30] and assessed the organization of components like fullerenes in optoelectronically active materials.

[36] In addition, the group has explored the use of novel redox-active organic materials in batteries, with an emphasis on compounds with unique structures and properties that can be easily synthesized from abundant renewable resources like biomass.