Jamestown is a village in northeastern Moniteau County, Missouri, United States.

Jamestown had its start in 1846 when E. H. and S. L. James established a country store at that point.

[8][9] The village is located on Missouri Route 87, approximately 12 miles (19 km) northeast of California, the county seat.

Factory Creek is an east-flowing direct tributary of the Missouri River, while the two branches flow southeast to Moniteau Creek, also a tributary of the Missouri.

36.6% of all households were made up of individuals, and 18.6% had someone living alone who was 65 years of age or older.

The racial makeup of the town was 97.12% White, 0.79% Native American, 0.26% Asian, 0.26% Pacific Islander, and 1.57% from two or more races.

36.0% of all households were made up of individuals, and 16.0% had someone living alone who was 65 years of age or older.