Blake grew up in Chicago before moving to Washington DC in 1993, where she attended The American University.
She has worked alongside Jeff Buckley, Tricky, Ric Ocasek (The Cars), Josh Freese (A Perfect Circle, The Vandals & Nine Inch Nails), and Danny Lohner (Nine Inch Nails, David Bowie & Marilyn Manson).
In 2010 she collaborated with a select group of artists on the movie soundtrack for "9191" including Hesta Prynn, Dave Lombardo (Slayer), Oliver Ackermann of A Place To Bury Strangers, Mike Conte of Early Man and snowboarder Jamie Lynn which won the ESPN Snowboard Picture Awards for Best Soundtrack as well as Best Soundtrack at the Summit Action Sports Film Festival.
In 2011, Jamie co-wrote and performed the song "Souls," with Japanese Alt Rock band the HIATUS.
She appears on two Live DVD releases with the HIATUS adding vocals to "Souls," "On Your Way Home," "Flyleaf" and "The Flare, " and guested on the band's live at Budokan taping, performing the songs "Souls" and "Tales of Sorrow Street."
In 2024 Blake contributed background vocals to Alkaline Trio's tenth album, Blood, Hair, and Eyeballs, it was released on January 26, 2024.