[10] Curtis received another Golden Globe for her portrayal of Hannah Miller on ABC's sitcom Anything but Love (1989–1992), and earned a nomination for a Primetime Emmy Award for Outstanding Lead Actress for the television film Nicholas' Gift (1998).

[6] Curtis has written numerous children's books, including Today I Feel Silly, and Other Moods That Make My Day (1998), which made The New York Times's best-seller list.

[26] She appeared as Nurse Lt. Barbara Duran in the short-lived comedy series Operation Petticoat (1977–1978),[27] based on the 1959 film that starred her father, Tony Curtis.

The producer, Debra Hill, specifically cast Curtis because her mother, Janet Leigh, had been known as a horror icon due to her Oscar-nominated performance in Psycho.

The film, for which she earned a Genie Award nomination for Best Performance by a Foreign Actress, was similar in style to Halloween, yet received negative reviews which marked it as a disposable entry in the then-popular slasher genre.

That year, Curtis also starred in Terror Train, which opened in October and met with negative reviews akin to Prom Night.

[10] Curtis's roles in the latter two films served a similar function to that of Strode—the main character whose friends are murdered and is practically the only protagonist to survive.

[34][35] Although the film was a box office bomb in Australia and Franklin later regretted not increasing the size of Curtis's role, it has achieved a cult following and was championed by Quentin Tarantino.

[46] Curtis received a Golden Globe Award for her work in the 1994 action-comedy film True Lies, directed by James Cameron.

[48] She earned another Golden Globe Award nomination for her work in TNT's adaptation of the Wendy Wasserstein play The Heidi Chronicles (1995).

[49] Curtis appeared in Fierce Creatures in 1997, alongside her three A Fish Called Wanda costars: John Cleese, Kevin Kline, and Michael Palin.

[citation needed] In 1998, she starred in the CBS television film Nicholas' Gift, for which she received a Primetime Emmy Award nomination,[11] and reprised her role of Laurie Strode for the third time in Halloween H20: 20 Years Later.

[53] In 2000, Curtis was honored with the Hasty Pudding Woman of the Year award[54] and appeared in the crime comedy film Drowning Mona, starring Danny DeVito and Bette Midler.

The following year, she starred as Geoffrey Rush's wife in the spy-triller film The Tailor of Panama and appeared in Billy Bob Thornton's Daddy and Them.

[6] She also received a Grammy Award nomination that same year for Best Spoken Word Album for Children for the audiobook The Jamie Lee Curtis Audio Collection.

The following year, she appeared as herself along with her True Lies co-star Arnold Schwarzenegger in the comedy film The Kid & I and hosted the CBS program A Home for the Holidays.

[61] In 2012, she appeared in five episodes of the military drama series NCIS, playing the role of Dr. Samantha Ryan, a potential romantic interest of Special Agent Gibbs (Mark Harmon).

[65] From 2015 to 2016, Curtis had a lead role as Cathy Munsch on the Fox satirical horror comedy series Scream Queens, which aired for two seasons.

"[72] In 2019, Curtis appeared as Linda Drysdale-Thrombrey, the eldest daughter of novelist Harlan Thrombey (played by Christopher Plummer) in Rian Johnson's mystery film Knives Out, which earned positive reviews and over $300 million at the global box office.

The graphic novel was published in July 2023 by Titan Comics, written by Curtis and filmmaker Russell Goldman, and illustrated by Karl Stevens.

[116] In March 2012, Curtis was featured with Martin Sheen and Brad Pitt in a performance of Dustin Lance Black's play 8—a staged reenactment of the federal trial that overturned California's Prop 8 ban on same-sex marriage—as Sandy Stier.

[117] The production was held at the Wilshire Ebell Theatre and broadcast on YouTube to raise money for the American Foundation for Equal Rights.

[120][121] Curtis endorsed Hillary Clinton in the 2016 presidential election, and was a vocal critic of President Donald Trump during his term in office.

[122] Curtis showed support for Marianne Williamson in the primaries[123] and endorsed Kamala Harris in the 2024 presidential election[124][125] as well as Adam Schiff for the 2024 Senate race in California.

[129] Beginning in 1990, Curtis and her father, Tony, took a renewed interest in their family's Hungarian Jewish heritage, and helped finance the rebuilding of the "Great Synagogue" in Budapest, Hungary.

Curtis is also involved in the work of the Children Affected by AIDS Foundation, serving as the annual host for the organization's "Dream Halloween" event in Los Angeles, launched every year in October.

[132][133] Curtis plays a leadership role for Children's Hospital Los Angeles and supported the 2011 opening of a new inpatient facility for the organization.

[147] She became sober from opiates in 1999 after reading and relating to Tom Chiarella's account of addiction,[17] and has called her own recovery the greatest achievement of her life.

[148] She is a fan of the video game World of Warcraft and the manga One Piece,[149] and has worn disguises that allowed her to attend Comic-Con, EVO,[150] and BlizzCon[151] incognito.

In 2021, Curtis received the Golden Lion for Lifetime Achievement during the 78th Venice International Film Festival and said, "I feel so alive, like I'm this 14-year-old person just beginning their life.