He also served as the President of the Chamber of Deputies from 2013 to 2017,[1] and was acting minister of Foreign Affairs from June to October 2018 and from 12 to 21 April 2021.

Prior to his election to parliament, Hamáček worked as an adviser to two prime ministers,[which?]

In August 2018, Hamáček helped negotiate the release of two workers from a German humanitarian group in Syria, and traveled to Damascus for the handover of the workers; the Czech Republic is the only country in Europe that maintains diplomatic relations with Syria.

[3] In 2021, Seznam Zprávy [cs] reported that Hamáček was considering negotiating with Russia not to disclose evidence of Russia's involvement in the 2014 Vrbětice ammunition warehouses explosions in exchange for 1 million doses of Sputnik V vaccine.

[5] He left the party in June 2024, following another poor performance in the 2024 European Parliament election.