His first role in cinema was Alexander von Humboldt in the East German film Die Besteigung des Chimborazo [de].

[1] In April 2021, Liefers was a leading figure of a group of German actors criticizing the coronavirus policies in Germany, with the campaign #Allesdichtmachen (“shut everything down”).

In the German television series Tatort, Liefers plays Professor Dr. Karl Friedrich Boerne, the director of the Institute of Legal Medicine and Forensics at the University of Münster.

Karl-Friedrich Boerne loves the good things in life, plays golf, fences and is fond of classical music, especially if it's loud.

The idiosyncratic, quirky forensic physician and the quiet, down-to-earth police officer share a close partnership both at work and closer to home.