Jan Mohammad Khan (died July 17, 2011) was a politician in Afghanistan, who served as Governor of Oruzgan Province from January 2002 to March 2006, member of the National Assembly, and a special adviser to President Hamid Karzai.

He later joined Jabha-i-Nijat Milli or National Salvation Front, another jihadi movement led by Sibghatullah Mojaddedi, and remained with the group until the victory of the mujaheddin.

Khan quit his job during the Taliban era and spent three years in a Kandahar jail on charges of working for former King Zahir Shah.

Thus no western governments objected when President Karzai replaced Khan as governor, giving him a nominal job in the Ministry of Tribal Affairs.

[5][7] They stated that Khan's killing was punishment for all his deeds in the past, but members of the Afghan National Assembly accused Pakistan's Inter-Services Intelligence (ISI).

[11] Bismillah Khan Mohammadi, the Interior Minister of Afghanistan, stated that the mobile phones recovered from the attackers showed incoming calls from Pakistan right before conducting the assassination.