Provost was a prolific master who left his early workshop in Valenciennes to run two workshops, one in Bruges, where he was made a burgher in 1494, the other simultaneously in Antwerp, which was the economic centre of the Low Countries.
He met Albrecht Dürer in Antwerp in 1520, and a Dürer portrait drawing at the National Gallery, London, is conjectured to be of Provost.
The styles of Gerard David and Hans Memling can be detected in Provoost's religious paintings.
Surprising discoveries can still be made: in 1971 an unknown and anonymous panoramic Crucifixion from the village church at Koolkerke was identified as Provost's.
It is on permanent loan to the Groeningemuseum, Bruges, which has several works of Provost.