[2] Hemessen played an important role in the development of genre painting, through his large scenes with religious or worldly subjects, set in towns with contemporary dress and architecture.
One of his best known works, the Parable of the Prodigal Son, expresses a religious theme through a pure genre painting set in a tavern and can be regarded as an important early statement of the merry company tradition.
Van Hemessen was one of the earliest Netherlandish artists to exploit the genre character of biblical subjects often for a moralizing purpose.
[8] His Mannerist style is characterised by muscular and palpably three-dimensional figures, a densely packed foreground of abruptly cropped forms, and vigorous, even flamboyant gestures.
He commenced his compositions on this theme with a 1536 painting on a religious subject, i.e. the Parable of the Prodigal Son (Royal Museums of Fine Arts of Belgium).
The foreground of the composition shows the prodigal son during his days of high living in the company of prostitutes, music, wine and gambling.
The composition clearly carries the moral lesson that one needs to see beyond the earthly pleasures depicted in the foreground to find the path of redemption, which is shown in the background.
Van Hemessen produced tavern and brothel scenes that address the theme of unbridled living where drinking causes more sinfulness.
[9] The depiction of his tavern and brothel scenes may have been intended more to please the viewer by a display of the artist's skill and the humor of the subject matter than a high moral judgment.
The story provided van Hemessen with an excuse to paint a scene contrasting people busily engaged in commercial activities, in particular money changing or counting, and the serene Jesus.
In the immediate foreground is Matthew, whose arms and head are depicted in dramatic foreshortening while he turns toward Jesus in response to his call.
Two of Matthew's colleagues are not aware of the momentous event taking place and they continue with their work of counting money and recording payments.
[7] Another representative work of Jan Sanders van Hemessen with a moral message is The Surgeon of 1555 (Museo del Prado, Madrid).
[15] His style of portrait painting played an important role in the popularity of portraiture in northern Europe from circa 1540 onwards.