In 2023, she made a "quick comeback, just to say good bye and play the final Grand Slam tournaments".

At the Family Circle Cup in Charleston, Čepelová scored the biggest win of her career, defeating world No.

Čepelová would go on to reach her first WTA tournament final with victories over Elena Vesnina, Daniela Hantuchová, and Belinda Bencic.

[4] Playing at the Indian Wells Open, Čepelová lost in the first round to qualifier Lucie Hradecká.

Last year finalist at the Family Circle Cup, Čepelová lost in the second round to fourth seed Sara Errani.

[8] Seeded eighth at the Open Saint-Gaudens, she reached the final where she was defeated by María Teresa Torró Flor.

At the Nottingham Open, Čepelová's first grass-court tournament of the season, she lost in the first round of qualifying to Donna Vekić.

[11] At Wimbledon in 2016, Čepelová defeated Garbiñe Muguruza in the second round, her third top-three win, before losing to Lucie Šafářová in an epic three-set match.

Beginning the season at the Australian Open, Čepelová withdrew from her first round of qualifying match against Kurumi Nara.