In 2007, Kramer appeared in a recurring role on the NBC sports drama television series Friday Night Lights.

Kramer played the role of high school student Portia Ranson and made her debut in the first season's second episode "The Jet Set".

Kramer played the role of a sorority girl who seduces the character Turtle (Jerry Ferrara), and appeared in four episodes.

In June 2009, it was announced Kramer would star in the CW drama television series seventh season of One Tree Hill.

Kramer played the role of Alex Dupre, an actress and tabloid darling who becomes the new face of Brooke Davis's fashion line, "Clothes Over Bros", and creates havoc for the residents of Tree Hill.

Initially Kramer's appearance on the show was meant to be in a recurring form, but her role was upgraded to a series regular by the season's fourteenth episode, "Family Affair".

In March 2012, Kramer made the announcement that she would no longer be making regular appearances in the show's ninth and final season, as she decided to focus on her music career.

In April 2011, Kramer released another promo track, titled "Whiskey", which she also performed on One Tree Hill.

[7] In February 2012, Kramer was cast as the protagonist in the independent drama film, Heart of the Country, playing the role of a privileged young woman, Faith Carraday,[8] who is following her show-biz dreams but leaves it all and moves to rural North Carolina after her husband is jailed for Wall Street fraud.

On June 1, 2012, Kramer made her first televised live performance on Fox & Friends to promote her debut album.

On June 5, 2013, Nationwide Insurance released the first of a series of commercials in its "Join the Nation" campaign, featuring Kramer as a stealthy woman dressed in black leather who follows a team of burglars and replaces the items they steal with newer versions to promote Nationwide's "Brand New Belongings" initiative.

[11] A second commercial, released in April 2014, featured Kramer's character replacing items in a fire-blackened apartment to promote Nationwide's renters' insurance.

[12] In November 2014, Jana reprised her Nationwide role, this time as a sexy Santa Claus-like figure replacing items during Christmas season.

It is based on the true story on how Morgan was gaslit by her ex-husband Rodney Metzer (portrayed by Austin Nichols).

[19] On December 22, 2009, Kramer became engaged to actor Johnathon Schaech, whom she had met on the set of Prom Night.

[23] In August 2014, Kramer began dating Washington Redskins tight end Mike Caussin, whom she met on Twitter.

[34] On April 20, 2021, Kramer filed for divorce from Caussin, citing "inappropriate marital conduct, irreconcilable differences and adultery".

[39][40] In January 2023, Kramer publicly confirmed via Instagram her relationship with Allan Russell, a former Scottish soccer player who created Superior Striker, a coaching program.