During her thirty-year career, she performed on stage, radio, and television despite chronic health problems due to injuries sustained in a 1943 plane crash.

She met vaudeville performer Don Ross when they auditioned for the same job at WLW radio station in Cincinnati.

Convinced that she was star material, Ross became Froman's unofficial manager and persuaded her to move to Chicago, where he worked for NBC radio.

That year, Froman moved to New York City, where she appeared on Chesterfield's Music that Satisfies radio program with Bing Crosby.

On January 4, 1948, Froman joined the cast of The Pause That Refreshes, a Sunday evening music program sponsored by Coca-Cola on CBS.

"[12] The famous composer and producer Billy Rose, when asked to name the top ten female singers, is reported to have replied, "Jane Froman and nine others.

[16] The very first hit song to be introduced on television, I Believe, was written for Froman by the show's musicians, Ervin Drake, Irvin Graham, Jimmy Shirl, and Al Stillman, and earned her a gold record in 1953.

Froman was severely injured as the result of the crash on February 22, 1943 of the Yankee Clipper, a Boeing 314 flying boat operated by Pan Am.

"[1] The fourth officer, John Curtis Burn, whose back was broken in the crash, fashioned a makeshift raft from portions of the wrecked plane to help keep himself and Froman afloat.

[18] Froman was a celebrity guest on the March 1, 1953, episode of What's My Line, when panelist Hal Block reminded her that he was supposed to be on the same flight, which she confirmed.

[19] Jane Froman and fellow survivor Gypsy Markoff sued Pan American using the services of lawyer Harry A. Gair, a pioneer in the field of aviation crash litigation.

[20][21][22] Froman's life story was the subject of the movie With a Song in My Heart (1952), starring Susan Hayward as Jane.

Froman later moved back to Columbia, Missouri, and rekindled her relationship with an old college friend, Rowland Hawes Smith.

[27] Froman died April 22, 1980, aged 72, at her home in Columbia, Missouri[23] of cardiac arrest caused by chronic heart and lung disease.

[30] In 1957, she started the Jane Froman Foundation, which assisted the children's hospital at the Menninger Clinic, which the funds from her many fan clubs help support.

Froman volunteered with numerous charitable organizations, two being the Easter Seals campaign, which helps individuals with developmental disabilities, and the Missouri Mental Health Association.

"[18] A DVD of the movie With a Song in My Heart with added new segments was premiered on November 9, 2007, and is now widely distributed by Fox Home Entertainment.