[5] It was in her mature teenage years that she joined 3RRR Radio in Melbourne, presenting a Sunday afternoon (4pm-7pm) new music show called Calamity.

[6][7] In 1998, she recorded with Australian band Underground Lovers, under the Japanese pseudonym "Mitsuame"; covering Can's 1976 song "I Want More" (from their album, Flow Motion)[8] Gazzo relocated to London, England in 1999, sharing a flat with The Prodigy founding member and former dancer Sharky.

Her time there included a three-week stint producing Russell Brand on-air before he was sacked by the station for bringing in a homeless man.

In February 2006 she hosted the first ever Cancer Research UK "Rock Memorabilia" auction at Abbey Road Studios, helping to raise £130,000.

Her first major broadcast for Channel [V] was presenting the network's Live Earth coverage from Sydney Football Stadium on 7 July 2007.

She has also presented from the Homebake festival, Splendour in the Grass, the ARIA Awards red carpet, Sound Relief and the Big Day Out.

[19] In June 2012, Gazzo moved to Max, a 24-hour music platform on Foxtel as a full-time host and VJ, presenting countdowns and interviews.

[22] In August 2019, Jane was chosen as the opening DJ for Hugh Jackman, on the Melbourne leg of his Australian concerts at Rod Laver Arena, playing six shows as his main support act.

[28][29][30] In January 2023, Jane coordinated the reworking of the 1997 Michael Hutchence solo hit, 'Rooms for the Memory 2023' alongside Adalita and Nick Launay to help raise funds for the song's composer Ollie Olsen who was diagnosed with Multiple System Atrophy.