She was Executive Director of Renfrew Center Foundation for Eating Disorders where she helped to develop a program that stresses activism as a tool for recovery, later she became the lead consultant on the 2006 documentary film Thin.

[9] Afterward she became the executive director of Young Democrats of America[10] where she met her husband Scott Kleeb while he was campaigning for a congressional seat.

Kleeb and Thompson held meetings with landowners and locals who would be affected by the pipeline, either farms in the direct path or ranches that depend on the Ogallala Aquifer.

[16] In June 2016 Kleeb was elected as Chair of the Nebraska Democratic Party by 42 votes out of 410 cast defeating 2014 gubernatorial nominee Chuck Hassebrook, with Frank LaMere winning first vice-chair.

[17] On August 29, 2016, it was announced that Kleeb would serve as the treasurer and board member of Our Revolution, a progressive 501(c) organization created as an offshoot of the Bernie Sanders 2016 presidential campaign.