The family moved to Sydney in 1960, where her father became a technical education instructor at the School of Sheep and Wool and later worked for Allied Feed Mills and Inghams.

[1] While living in Sydney, Prentice was a state vice-president of the Young Liberals and chairman of its Mosman branch.

[4] At the 2010 federal election, Prentice comfortably defeated sitting local member, Michael Johnson, who was expelled from the Liberal Party in May 2010 for allegedly bringing the party into disrepute, having used his political position and entitlements to further his business interests and those of a company set up almost exclusively to fund his prolific overseas travel.

Prentice was appointed Assistant Minister for Disability Services in February 2016, as a member of the First Turnbull Ministry.

[1] In May 2018, she was defeated for LNP preselection to recontest her seat at the 2019 Australian federal election by Julian Simmonds, a member of the Brisbane City Council.