[4] After leaving Barnard, she joined the apprentice school of the Berkshire Playhouse at Stockbridge, Massachusetts, where for six months she played a variety of roles.

One of her first jobs on Broadway was as understudy to Rose Hobart in a production of Trade Winds—a career move that cost her her listing in the New York Social Register (she later was relisted upon her marriage).

Receiving favorable notices on Broadway and celebrated for her understated beauty, Wyatt made the transition from stage to screen and was placed under contract by Universal Pictures.

She reflected on Lost Horizon sixty years later in St. Anthony Messenger magazine: During the war, they cut out all the pacifist parts of the film—the High Lama talking about peace in the world.

[6]Other film appearances included Gentleman's Agreement with Gregory Peck, None but the Lonely Heart with Cary Grant, Boomerang with Dana Andrews, and Our Very Own with Farley Granger.

Her film career suffered due to her outspoken opposition to Senator Joseph McCarthy, the chief figure in the anti-Communist investigations of that era, and was temporarily derailed for having assisted in hosting a performance by the Bolshoi Ballet during the Second World War, though it was at the request of President Franklin D.

[7] Wyatt returned to her roots on the New York stage for a time and appeared in such plays as Lillian Hellman's The Autumn Garden, opposite Fredric March.

In 1963, she portrayed Kitty McMullen in "Don't Forget to Say Goodbye" on the ABC drama Going My Way, with Gene Kelly and Leo G. Carroll, a series about the Catholic priesthood in New York City.

In 1969, she made a guest appearance on Here Come the Brides, but did not have any scenes with Mark Lenard, who was starring on the show as sawmill owner Aaron Stemple.

[citation needed] In 1976, she guest-starred in an episode of Gibbsville, and she appeared as Anna, mother of the Virgin Mary, in the 1978 television film The Nativity.