As a 17-year-old at the 1988 Summer Olympics in Seoul, South Korea, she won a silver medal as a member of the second-place U.S. team in the women's 4×100-meter medley relay, together with her teammates Beth Barr (backstroke), Tracey McFarlane (breaststroke), and Mary Wayte (freestyle).

[1] Jorgensen received an athletic scholarship to attend Stanford University, where she swam for the Stanford Cardinal swimming and diving team in National Collegiate Athletic Association (NCAA) and Pacific-10 Conference competition.

In 1992–93, she was the recipient of the Honda Sports Award for Swimming and Diving, recognizing her as the outstanding college female swimmer of the year.

[2][3] In 2021, she was honored to be a part of the CSCAA's 100 Greatest Collegiate Swimmers of All Time.

[4] Jorgensen is the current COO of Swim Across America, a national non-profit organization that has raised over $100 million for cancer research, prevention and treatment through swimming events all over the United States.