[9] When she was 22, Weiss was invited to learn the drums to join an all-girl trio called the Furies as their replacement drummer for a West Coast tour.

[9] She moved to Portland, Oregon in 1989 and soon after began playing with former Donner Party leader, Sam Coomes, in a band called Motorgoat.

"[11] On July 1, 2019, Sleater-Kinney announced via social media that Weiss would be leaving the group and would not be joining their upcoming fall tour.

[12] Weiss and Sam Coomes formed Quasi in 1993, and the band has remained active both as a duo and a trio, featuring Joanna Bolme from 2007 to 2011, for the past 30+ years.

Beginning in September 2010, she drummed in Wild Flag, with Carrie Brownstein (Sleater-Kinney), Mary Timony (Helium), and Rebecca Cole (the Minders).

[13] She has also played for Bright Eyes, Junior High, the Shadow Mortons, the Go Betweens, Sarah Dougher, Elliott Smith, and one Goldcard song.

On June 4, 2007, she performed with Bright Eyes on the Late Show with David Letterman before joining the band for their summer European tour.