"Janie, Don't Take Your Love to Town" is a song by American rock singer Jon Bon Jovi.

It was released in September 1997 as the third single from his second solo album, Destination Anywhere (1997).

Commercially, the song reached number 13 on the UK Singles Chart and number 18 on Canada's RPM 100 Hit Tracks chart.

The song features a music video which was released on the DVD Destination Anywhere: The Film.

British magazine Music Week rated "Janie, Don't Take Your Love to Town" three out of five, adding, "Written after a row with Mrs Bon Jovi, the third single from Destination Anywhere is a plaintive cry, delivered with passion.