He made his political debut in the 2011 general election as part of a six-member PAP team contesting in Pasir Ris–Punggol GRC, and won 64.79% of the vote.

He was also compared with Chen Show Mao, a foreign-born Workers' Party candidate who had served national service as a second generation Singapore Permanent Resident.

[5] Low Thia Khiang, the Workers' Party chief, called for an amendment to the Constitution to allow only male candidates who have served national service to run for elections.

[8] Puthucheary contested as part of a six-member PAP team in Pasir Ris–Punggol GRC in the 2015 general election and they won with 72.89% of the vote against the Singapore Democratic Alliance.

[1] During the 2020 general election, Puthucheary contested as part of a five-member PAP team in Pasir Ris–Punggol GRC and they won with 64.16% of the vote against the Singapore Democratic Alliance.

Dominic Puthucheary was detained in February 1963 during Operation Coldstore[9][10] but was released ten months later and barred from entering Singapore until 1990, when he was elected MP for Nibong Tebal in Penang, Malaysia.

[11] Dominic’s older brother James was also a founding member of the PAP who left to join Barisan Sosialis and was detained during Operation Coldstore.