Only young adults are spared, among them a quartet of drunken high school kids in suburban Seattle, two teens whose fake IDs have gained them entry to a New York City nightclub, a cocky young doctor in a Texas hospital, a pair of tough-talking inmates in a Pittsburgh jail, and Sarah and Joshua Levy who desperately search the ancient scroll of their granduncle Elijah for clues to the apocalyptic event.

After everyone on Earth over twenty dies, the awakened Demon called Lilith continues to spread her influence, while the teenagers chosen to stop her hope to unleash the power of an ancient encoded scroll.

In a world where turning twenty-one seems to mean certain death by a horrible Plague, the forces of the Demon Lilith and the Visionaries who believe in the Chosen One continue to be drawn west toward a final confrontation.

As the Demon Lilith continues to grow in strength, some of the world's teenage survivors worry about finding a cure for the plague that has killed all the adults, while others try to party themselves to death.

[2] The series draws heavily upon common literary tropes and characters found in both religious texts and popular fiction, including the apocalyptic concept and the introduction of demonic forces.