The Japan–USA Softball All-Star Series (Japanese: 日米対抗ソフトボール, Hepburn: Nichibei Taikō Sofutobōru) is an annual tour of Japan made by the United States women's national softball team since 2016, contested in a three-game series against the Japan women's national softball team.

In the beginning of all games the Japanese and American national anthems are both played.

The inaugural game was held at Tokyo Dome on June 23, 2016, with 31,448 spectators in attendance.

The editions 2020 and 2021 were canceled due to the COVID-19 pandemic, then the series resumed in 2022.