The southern terminus and starting point of National Route 167 lies just one block south of Kashikojima Station on the Ago Bay island, Kashiko that lies within the city of Shima.

Traveling north off the island parallel to the Shima Line, the highway meets National Route 260 at a junction near Ugata Station.

Near Nakanogō Station in Toba, the highway has a junction with the paired highways: National Routes 42 and Route 259, which have just entered Mie Prefecture via the Ise-wan Ferry from Cape Irago in Aichi Prefecture.

Upon crossing into the city of Ise, Routes 42 and 167 meet the eastern terminus of the Ise Futami Toba Line, a limited-access highway signed as a bypass of National Route 42.

[1] National Route 167 was originally designated on 18 May 1953 as a second-class national highway connecting then-extant town Ago (the former town was merged into Shima in on 1 October 2004) to Ise.