National Route 48 (国道48号, Kokudō yonjūhachigō) is a national highway of Japan that connects the capital cities of Miyagi Prefecture and Yamagata Prefecture, Sendai and Yamagata.

It carries traffic across the Ōu Mountains that separate the two cities.

The highway's eastern terminus lies at a junction with National Route 45 in Sendai's Aoba ward.

[3] It replaced the original, congested two-lane section of National Route 48 along the Hirose River.

[3] The Ayashi Bypass to the west of the Sendai Nishi Road along the route was opened in 1994.