National Route 5 (国道5号, Kokudō Go-gō) is a major highway on the island and prefecture of Hokkaido in northern Japan.

The 288.5-kilometer (179.3 mi) highway begins at an intersection with National Routes 279 and 278 in Hakodate.

National Route 5 traces its origin to the Sapporo Hondō [ja], a road designed by Horace Capron, in 1872.

The Sapporo Hondō connected Sapporo to Hakodate at the southern end of the Hokkaido where sea connections to the main island of Japan, Honshu, were located.

[2] On 4 December 1952, the Cabinet of Japan designated the Sapporo Hondō as First Class National Highway 5.