He first came to prominence in 2007 when he competed for the New Jersey Tigers in the World Combat League and made it to the finals of the New York Golden Gloves tournament that same year.
Miller was due to challenge Anthony Joshua for the WBA (Super), IBF, WBO, and IBO heavyweight titles in 2019, but was denied a license to box after failing multiple drug tests.
[8] Miller won the fight by TKO in the first round due to the ring doctor stopping the match because of a cut Darius Whitson received from an accidental headbutt.
[9] Miller took another gap from boxing for 11 months, returning to the ring in April 2012 at the Cordon Bleu in Woodhaven, New York, against American boxer Donnie Crawford, stopping him 2 minutes and 38 seconds of round one.
[11] In January 2014, Miller fought at the Harrah's Philadelphia in Chester, Pennsylvania, against Jon Hill (6–4, 5 KOs), winning the fight via technical knockout in round 4.
[9] Miller had his first fight of 2016 on January 23 at the Casino Del Sol in Tucson, Arizona, for the interim WBA-NABA heavyweight title against Donovan Dennis (12–2, 10 KOs).
In the post-fight interview, Miller again called out top heavyweights Wladimir Klitschko, Tyson Fury, Anthony Joshua and Deontay Wilder.
[19] Salita Promotions announced that Miller would be fighting on the main event of ShoBox: The New Generation on August 19 at the outdoor Rhinos Stadium in Rochester, New York.
Miller started making noise in December 2016 when new WBO heavyweight champion Joseph Parker listed him as a potential first defence along with British boxers Hughie Fury and David Price.
The news initially came when the WBO stated Parker could make a voluntary defence after mandatory challenger David Haye decided to take up a grudge match against fellow Brit Tony Bellew.
[36] A day later it was revealed that 37 year old former world title challenger Mariusz Wach (33–2, 17 KOs) would be Miller's opponent for his HBO debut.
"[44] A deal was not reached and on February 6, ESPN reported that Miller would instead fight 37 year old French contender and former world title challenger Johann Duhaupas (37–4, 24 KOs) as part of a doubleheader including Daniel Jacobs vs. Maciej Sulęcki, at the Barclays Center, in Brooklyn, New York on April 28, live on HBO.
At the time, the titleholder Manuel Charr was going through a failed drugs test, as the belt was not yet vacant, Greg Cohen, Miller's co-promoter stated he would likely fight 45 year old boxer Fres Oquendo or WBA 'interim' champion Trevor Bryan.
[64] On October 19, terms were agreed for Miller to challenge Oquendo (37–8, 24 KOs), for the soon-to-be vacant WBA 'regular' belt on November 17 at the Boardwalk Hall in Atlantic City, New Jersey.
Oquendo, last fought in 2014, was legally owed a WBA 'regular' title opportunity after winning a lawsuit on the back of his loss against then belt-holder Ruslan Chagaev.
Prior to the scheduled fight, Miller tested positive for GW501516, causing the New York State Athletic Commission (NYSAC) to deny him a license to box.
[77][78] On October 31, 2019, it was reported that Miller was on the verge of a comeback and close to signing a co-promotional deal with Bob Arum's Top Rank Inc, which meant he would appear on ESPN going forward.
[82] Following the suspension by the WBA, on June 16, 2020, it was announced that Miller was scheduled to make his ring return against Jerry Forrest (26–3, 20 KOs) on July 9, at the MGM Grand Conference Center in Paradise, Nevada.
[88] WBC President Mauricio Sulaiman told Sky Sports that Miller failed to enrol in their Clean Boxing Program, multiple times, which meant he could not get ranked by them.
[96] On May 15, it was announced a date had been set for Miller to headline a Triller Fight Club card on June 25 against Nigerian Onoriode Ehwarieme (20–2, 19 KOs) at the Kia Forum in Inglewood, California.
[107] Miller's next fight was announced by promoter Anatoly Sulyanov of Hardcore Boxing, to take place on March 18, 2023, against former WBA regular heavyweight champion Lucas Browne.
[113] In November 2023, Riyadh Season announced a blockbuster card which would take place on on December 23, 2023, with Anthony Joshua vs. Otto Wallin as the headline.
One of the undercard bouts announced was Miller making his second appearance of the year against British heavyweight contender Daniel Dubois.
[140][141] Jarrell Miller fought Antonio Zepeda in an exhibition match on June 11, 2023, on the undercard of Floyd Mayweather vs. John Gotti III.
On May 3, 2008, he defeated K-1 veteran Pat Barry at the WCL Eastern & Western Conference Finals in San Antonio, Texas, the biggest feat of his career at that point.
[144][145] His exploits won him admirers, and in 2012, after he knocked out Radu Spinghel in New York City, he was recruited by K-1, historically the world's premier kickboxing organization.
[147][148] Miller was able to knock May out with an uppercut in the first round to advance to the K-1 World Grand Prix 2012 in Tokyo final 16 on October 14, 2012, where he was drawn against Arnold Oborotov.
[152] The panel of judges all scored the bout for Cro Cop by unanimous decision, handing Miller his first professional loss and sending him out of the tournament.
[155] Replacing Sergei Kharitonov who withdrew from the fight due to a finger injury,[156] Miller rematched Mirko Cro Cop at Glory 17: Los Angeles in Inglewood, California, on June 21, 2014.
In 2014, Miller was suspended for nine months by the California State Athletic Commission (CSAC) after methylhexaneamine was found in a urine sample he gave for Glory 17: Los Angeles.