On May 26, 2009, after pitching just 252⁄3 innings for Triple-A Norfolk, he was called up to the Orioles' roster to replace injured outfielder Lou Montanez.

Berken earned his first major league win that day, giving up two runs in five innings in a 7–2 victory over the Toronto Blue Jays.

This led to Berken being named the "AL Les Sweetland Award winner" by SI writer Joe Posnanski for finishing the year as the worst starting pitcher in the American League.

On April 2, 2013, Berken signed as a minor league free agent with the Chicago White Sox for 2013 season.

[5] In 29 appearances split between the Double–A New Hampshire Fisher Cats and Triple–A Buffalo Bisons, he accumulated a 2–9 record and 4.43 ERA with 63 strikeouts across 105+2⁄3 innings pitched.