Mitchell started his career acting in minor roles in films such as the action-thriller Contraband (2012), and the neo-noir Broken City (2013).

Starting in 2018 he was cast in Lena Waithe's Showtime series The Chi until 2019 when he was accused of multiple allegations of misconduct and subsequently fired from the show.

Mitchell also received his second Screen Actors Guild Award for Outstanding Ensemble Cast in a Motion Picture nomination.

In 2018, Mitchell starred in the Lena Waithe's Showtime drama series The Chi, but did not return for a third season due to his misconduct allegations.

[5][6] In May 2019, Mitchell was fired from The Chi when showrunner Ayanna Floyd Davis and co-star Tiffany Boone accused him of sexual misconduct.

[8] While creator and showrunner Lena Waithe claimed that Mitchell had never acted inappropriately towards her, she knew of the allegations after filming had wrapped on season one of The Chi.

[9] Mitchell denied the multiple allegations of sexual harassment and misconduct against him saying, "I'm all for the Me Too movement...but I think in this situation, [Floyd Davis] tried to use it as a really, really ugly weapon".