For his role as David Foster Wallace in The End of the Tour (2015) he received a nomination for the Independent Spirit Award for Best Male Lead.

In 2023, he began starring as a therapist in the Apple TV+ series Shrinking, which he also co-created alongside Bill Lawrence and Brett Goldstein.

[20] Segel had recurring roles on CSI: Crime Scene Investigation as Neil Jansen and on Undeclared as Eric.

He played Marshall Eriksen on the CBS sitcom How I Met Your Mother; he had previously stated he would move on to other projects in 2013 when his contract expired,[21] but was convinced to finish the series after its ninth season in 2014.

Segel starred in the lead role of 2008's Forgetting Sarah Marshall, a film he wrote and Apatow produced with Shauna Robertson for Universal Pictures.

Those cloth creatures were custom-made by the Jim Henson Company, and the experience emboldened Segel to pitch his concept for a Muppets movie.

[27] For the 2010 comedy Get Him to the Greek, Segel co-wrote most of the soundtrack's music which was performed by the fictional celebrity singer, Aldous Snow, including Infant Sorrow.

Disney was unsure on how to take the request, as Segel had just appeared nude in Forgetting Sarah Marshall, but after realizing that he was a fan, the project was approved.

[34][35] In 2015, Segel received praise[36][37][38] for his portrayal of the late author David Foster Wallace in the independent biographical drama film The End of the Tour.

Segel created and starred in the American drama television series Dispatches from Elsewhere, which premiered on March 1, 2020, on AMC.

[41] He performed a wedding ceremony on The Tonight Show on July 6, 2010, for a couple that solicited his services by placing pictures of him around his hometown and the bar he frequently visited.