He played college football for the Ohio Northern Polar Bears before being signed by the New York Jets as an undrafted free agent in 2007.

As a rookie, he appeared in six games and recorded six tackles on special teams after spending the first nine weeks on their practice squad.

On October 7, 2009, Trusnik was traded to the Cleveland Browns by the New York Jets in exchange for wide receiver Braylon Edwards.

The Browns finished the season with the best kickoff return average starting position (31.4) in the NFL with Trusnik as a blocker.

In 2014, Trusnik caught his first career interception from a Tom Brady pass on December 14.

On March 31, 2015, the Carolina Panthers signed Trusnik to a 1-year deal as an unrestricted free agent.

He had previously worked with Vikings defensive coordinator, George Edwards, while he was the linebackers coach at Miami from 2012 to 2013.