In his last career collegiate game he made a total of 4 tackles, 2 sacks, and a forced fumble in a win over Savannah State.

Representatives and scouts from 23 NFL teams attended his Pro Day and four defensive line coaches from the Cincinnati Bengals, Pittsburgh Steelers, Philadelphia Eagles, and Tennessee Titans also came to watch Hargrave, along with 14 other prospects.

[4] Although analysts and scouts gave him positive reviews for his motor, playmaking ability, quick footwork, athleticism, and strength they also criticized him for his short arms, stocky frame, small hands, lack of instincts, and also considered him a raw talent.

[10] On November 20, 2016, Hargrave scored his first career NFL touchdown after Ryan Shazier stripped Cleveland Browns quarterback Josh McCown.

[14] The Steelers received a playoff berth after finishing atop the American Football Conference (AFC) North with an 11–5 record.

[15] On January 8, 2017, Hargrave started his first career playoff game and recorded one tackle, as the Steelers routed the Miami Dolphins 30–12 in the AFC Wild Card Round.

[16] After defeating the Kansas City Chiefs in the Divisional Round,[17] the Steelers went on to face the New England Patriots in the AFC Championship.

[24] In week 10 against the Los Angeles Rams, Hargrave recorded a strip sack on Jared Goff which was recovered by teammate Minkah Fitzpatrick who returned it for a 43 yard touchdown in the 17–12 win.

[28] In week 14 against the Saints, Hargrave recorded 2 sacks on Taysom Hill and recovered a fumble forced by Josh Sweat in the 24–21 win.

[30] During Week 3 against the Cowboys, Hargrave recorded two sacks on Dak Prescott which included a forced fumble in the endzone which was recovered by Fletcher Cox for a touchdown.

[32] In the Wild Card game against the Buccaneers, Hargrave recorded four tackles, two quarterback hits and a sack on Tom Brady in the 31–15 loss.

[33] As a result of his breakout campaign, Hargrave was announced as the injury replacement for Kenny Clark in the 2022 Pro Bowl.

[38] In Super Bowl LVIII, Hargrave recorded one sack, one fumble recovery, and six total tackles in the 25–22 overtime loss to the Chiefs.