He has also been a member of the New York Giants, Washington Commanders and Detroit Lions of the National Football League (NFL), and the Toronto Argonauts of the CFL.

[7][8][9] Leake became the first player in Big Ten Conference history to be named the Offensive and Special Teams Player of the Week for the same game after he rushed for 140 yards and three touchdowns and returned a kick 97 yards for a fourth score against Illinois.

[13][14] Following the end of the season Leake announced that he would be forgoing his final year of eligibility to enter the 2020 NFL draft.

[15] Leake signed with the New York Giants as an undrafted free agent on April 25, 2020,[18] but was waived on August 29, 2020.

[19] Leake signed with the practice squad of the Washington Football Team on November 19, 2020.

[29] He played in his first CFL game in the team's season opener on June 16, 2022, against the Montreal Alouettes where he was used primarily as a kick returner.