[7] While studying as a medical student at the Faculty of Medicine, University of Colombo, Jayawardena took a keen interest in politics and social work.

While working as a Specialist Surgeon at the Colombo National Hospital, he was also the family doctor of the late President Ranasinghe Premadasa.

[3] Meanwhile, he attended continuously in every Commonwealth and Inter-Parliamentary Sessions by advocating for the rights of the country's minorities.

Once he was invited by the United Nations High Commissioner for Refugees to deliver a speech on "Sustainable Voluntary Resettlement of Internally Displaced Persons" in Geneva.

He made several efforts to ensure the safety of the people living in the border villages of the North and East.

As an active social worker, Jayawardena started the 'Neth Pahan' medical program on TNL channel and worked 14 consecutive years.

[4] At the time of his death, he was a Member of Parliament for Gampaha District, Deputy General Secretary of the United National Party, President of the Jathika Sevaka Sangamaya and Chief Organizer of the United National Party for the Negombo electorate.