[3] De Lisser was born with the chronic liver disease Hepatitis C. This was passed on from her mother, who had possibly become infected through intravenous drug use.
[4] At 13, de Lisser went to Bryanston School, and left after completing her GCSEs to take her A Levels at the Fine Arts College in Hampstead, enabling her to attend medical appointments in London.
[11][12] De Lisser was one of the members of the Skinny Bitch Collective, an invitation-only workout group[13] that was criticised for its sexualisation of women working out, and for being exploitative and degrading.
[15] This was followed by de Lisser's television debut in 2014 with a minor role in the fourth season of the HBO fantasy series Game of Thrones as Tansy, a servant chased and killed by Ramsay Bolton's dogs.
In 2022, de Lisser appeared in the Peacock series Vampire Academy as Sasha Tanner[17] and the Swedish historical film Hilma.