Jean-Baptiste de Sénac (1693–1770) was a French physician, born in the district of Lombez in Gascony, France.

Beginning in 1723, Sénac practiced medicine in Paris, serving (from 1752 to 1770) as a personal physician to King Louis XV.

Sénac is remembered for important studies of the heart in an era when cardiological medicine was rudimentary.

In the treatise, he discusses heart disorders and diseases that he analyzed personally, as well as diagnoses that were determined by other physicians.

He was the first physician to describe the correlation between atrial fibrillation and mitral valve disease, as well as the first to provide a comprehensive study of cardiac hypertrophy.