Jean-Baptiste du Casse (2 August 1646 – 25 June 1715) was a French Navy officer, privateer, slave trader and colonial administrator who served as the first governor of Saint-Domingue from 1691 to 1700.

He subsequently joined the French navy and took part in several victorious expeditions during the Nine Years' War in the West Indies and South America.

During the War of the Spanish Succession, he participated in several major military engagements, including the Battle of Málaga and the siege of Barcelona.

For his service, du Casse was made a knight of the Order of the Golden Fleece by King Philip V of Spain.

His father Jacques was the son of Gaillard Ducasse, a minister in the Reformed Church of France, which designated the family as Huguenots.

He eventually sailed to France and offered half of his loot to the Crown; for this he was appointed Lieutenant in the French Navy by Louis XIV.

In the following months he plundered the English colonies in the vicinity, including Port Royal which had just been struck by a devastating earthquake.

[citation needed] In the video game Assassin's Creed IV: Black Flag, Du Casse's nephew serves as one of the antagonists and the first boss.

This character took to sea at a young age and fought alongside his real life uncle in the War for Spanish Succession, before deserting in favor of a brief tenure as a slave trader and subsequently as a mercenary prior to the game's start.