[3] Different productions have since enabled Spinosi to include musical friendships with artists such as Cecilia Bartoli, Marie-Nicole Lemieux, and Philippe Jaroussky, with whom he recorded the album Heroes for EMI-Virgin Classics, a disc whose sales achieved triple-gold status.

From 2007, Spinosi conducted new opera productions every season with the Ensemble Matheus at the Théâtre du Châtelet.

For several years, he has worked with stage directors, including Pierrick Sorin (for Rossini's La Pietra del Paragone in 2007 and 2014),[4] Oleg Kulik (for Monteverdi's Vespers for the Blessed Virgin in 2009), Claus Guth (for Handel's Messiah at the Theater an der Wien, 2009), Moshe Leiser and Patrice Caurier (for Rossini’s Otello at the Théâtre des Champs-Elysées and Salzburg Festival in 2014).

His most recent albums for Deutsche Grammophon, Lucifer with the Monte-Carlo Philharmonic Orchestra and Miroirs with the Ensemble Matheus, which both won the "Choc" award from Classica magazine.

In 2017 and 2018, he did a reunion with the Quebec ensemble Les Violons du Roy and the contralto Marie-Nicole Lemieux for the opera Carmen bringing together the forces of the Ensemble Matheus and the Castile and León Symphony Orchestra, Rossini's La Cenerentola at the Royal Swedish Opera, three productions at the Vienna State Opera (Carmen, The Barber of Seville and La Cenerentola) as well as a concert at the Prince's Palace of Monaco, leading the Monte-Carlo Philharmonic Orchestra.