He received his episcopal consecration on the following 30 April from Cardinal Pierre Eyt, with Bishop Jean Orchampt and Archbishop François Saint-Macary serving as co-consecrators.

[1] On 10 November 2007, Pope Benedict XVI named him Secretary of the Congregation for Catholic Education in the Roman Curia and bestowed upon him the personal title of archbishop.

[3] On 26 June 2012, Pope Benedict XVI appointed him the Archivist and Librarian of the Holy Roman Church.

[4] In March 2014 he announced that the Vatican Library was digitizing approximately 3000 handwritten manuscripts and considering extending the project to cover all its holdings.

[5] Bruguès served as President of the Organizing Committee of the Vatican Foundation Joseph Ratzinger - Benedict XVI for the Symposium on "The Gospels: History and Christology - Research of Joseph Cardinal Ratzinger, Pope Benedict XVI", which was held at the Pontifical Lateran University on 24–26 October 2013.