In 1986, the directors of SNCF (French State Railways) hired him to form a new architectural division.
With Étienne Tricaud, he laid the theoretical groundwork for the creation of new, large stations in a contemporary style, which he saw from the points of view of both urban planning and architecture: opening up the city, intermodal transport, traffic management, accessibility and commercial development.
In 1997, he won the competition for the new high speed train station in Seoul, Korea.
He and Tricaud created the multidisciplinary AREP agency (French: Amenagement, Recherche, Pole d'Echanges, "Management, Research, Interchange") as a wholly owned subsidiary of SNCF.
Duthilleul was a consultant on the Grand Paris project, working with Jean Nouvel and Michel Cantal-Dupart.