Guéhenno was elected Chairman of the Henri Dunant Centre for Humanitarian Dialogue (HD) board at the end of 2010.

From March to July 2012, he temporarily stood down from the board to serve as Deputy Joint Special Envoy of the United Nations and the League of Arab States on Syria.

He also served as associate director of the Arnold A. Saltzman Institute of War and Peace Studies at SIPA and directed the School's International Conflict Resolution specialization.

Guéhenno was named president and CEO of International Crisis Group in August 2014, succeeding Louise Arbour.

Guéhenno has published articles in many newspapers and magazines, including "The Impact of Globalisation on Strategy" in the International Institute for Strategic Studies' Survival, and "Globalisation and the International System" in the Journal of Democracy, as well as articles or chapters in Internationale Politik, Prospect, Paradoxes of European Foreign Policy, and Strategic Analysis.