He served in several government positions, including president of the Grand Conseil, intendant of Provence, then of Guyenne, and of Dauphiné.

He moved with his three sons – including François, the eldest, who was a member of Parliament for Bordeaux – to the colony.

All three sons married into other founding families of the colony after having been set up with various lands and positions within the area.

The establishment of Lauzon's family in the colony was probably intended to inspire confidence amongst the settlers and encourage agriculture in addition to the fur trade.

In 1653, Lauzon negotiated a peace treaty with the Mohawk, an Iroquois nation based in what is now New York.