A business lawyer by profession, he is a long-time member of the PDCI-RDA and has held various party posts.

[1] Under President Laurent Gbagbo, Ahoussou-Kouadio was appointed as Minister of Industry and the Promotion of the Private Sector on 5 August 2002[1] as part of a national unity government.

[1] He was the director of Bédié's campaign during the first round of the October–November 2010 presidential election; after Bédié placed third and gave his support to Alassane Ouattara, Ahoussou-Kouadio served as deputy director of Ouattara's campaign for the second round.

[3] However, he remained in office for less than a year; on 21 November 2012, President Ouattara appointed Foreign Minister Daniel Kablan Duncan, also a member of the PDCI, to replace Ahoussou-Kouadio.

In the government appointed on 12 January 2016, he held the post of Minister of State at the Presidency for Political Dialogue and Relations with the Institutions.