After two cup of coffee stints with the Royals, Conine was selected by the Marlins in the 1992 Major League Baseball expansion draft.

[5] Prior to the draft, Conine was considered a mediocre pitching prospect with a high earned run average and a "decent" slider.

Conine was selected by the Florida Marlins in the 1992 Major League Baseball expansion draft, and converted into a full-time left fielder.

[1] During the strike, Conine returned to the Marlins' Instructional League affiliate in Brevard County, Florida, to learn third base.

He batted .340 with nine home runs and 24 RBIs in June to earn National League Player of the Month honors and his second consecutive All-Star nod.

In his only career All-Star Game at-bat, he hit a go-ahead pinch-hit home run in the eighth inning and won the MVP award.

[1] Newly hired Marlins manager Jim Leyland shifted Conine back to first base in 1997, as the club had acquired free agent Moisés Alou to play left field.

As part of the "fire sale" of his franchise's best players, Conine was shipped back to the Kansas City Royals for minor league pitcher Blaine Mull.

On August 31, tied with the Philadelphia Phillies for the wild card playoff spot, the Marlins sent right-handed pitching prospects Denny Bautista and Don Levinski to Baltimore for Conine.

[13] Conine batted .239 with five home runs and fifteen RBIs over 25 games back in Florida, and the Marlins returned to the postseason for the second time in franchise history.

[1] In 2006, the Phillies were competing for the NL wild-card race and acquired Conine on August 27 for a player to be named later (infielder Ángel Chávez).

[1] When the Phillies signed free-agent Jayson Werth after the season, Conine became expendable, and was sent to the Cincinnati Reds for minor league prospects Bradley Key and Javon Moran.

His .409 batting average and four RBIs in 22 pinch hit at-bats made him an attractive player to the New York Mets, who were looking to add depth to their bench.

[23] On December 26, 2007, while training for the Ford Ironman World Championship in Kona, Hawaii, he crashed his bicycle while trying to avoid a car pulling out in front of him, and shattered his collarbone.

[24] Conine appeared as a color commentator on three Marlins Fox Sports Network telecasts in September 2008, filling in for Tommy Hutton.

[citation needed] On April 29, 2014, Conine was inducted into the Ride of Fame in Miami and a double decker tour bus was dedicated to him.