Jeffrey Scott Keppinger (born April 21, 1980) is an American retired Major League Baseball infielder.

He played for the New York Mets, Kansas City Royals, Cincinnati Reds, Houston Astros, San Francisco Giants, Tampa Bay Rays, and Chicago White Sox.

He compiled a .380 batting average at the University of Georgia where, in the 2001 College World Series, he hit a two-run home run off star pitcher Mark Prior.

His average soared even higher with the double-A Binghamton Mets and stayed above .300 with the triple-A Norfolk Tides earning him a call to the majors on August 20.

With a season-ending injury to starting third baseman Mark Teahen, Keppinger was expected to see some major league action.

Keppinger, batting against Manny Delcarmen, hit a ball just to the left of the right field foul pole for a three-run home run, breaking the 4–4 tie.

[6] On March 31, 2009, Keppinger was traded to the Houston Astros for minor league infielder Drew Sutton.

[7] Keppinger began the 2010 season with the Astros as the primary backup at second base to starter Kazuo Matsui.

[8] On July 19, 2011, Keppinger was traded to the San Francisco Giants for pitchers Henry Sosa and Jason Stoffel.